Ann Margaret Lewis began her writing career writing tie-in children's books and short stories for DC Comics. She then published two editions of Star Wars: The New Essential Guide to Alien Species for DelRey/Random House. Moving from licensed publishing, Ann began writing science fiction/fantasy, historical fiction, and Sherlock Holmes mysteries. Her first book, Murder in the Vatican: The Church Mysteries of Sherlock Holmes was the Independent Book Publisher's Award Winner for 2010 and a finalist for the Catholic Arts and Letters Award. She followed that with another Sherlock Holmes novel entitled The Watson Chronicles: A Sherlock Holmes Novel in Stories.

Her latest book, the first of a space opera trilogy entitled Warrior of the Kizan is her first novel for Superversive Press, and her work has appeared in the Superversive Press anthologies To Be Men and Luna (2020)